Resveratrol analogue,HS-1793, inhibits inflammatory mediator release from macrophages by interfering with the TLR4 mediated NF-κB activation

Food Science and Biotechnology - Resveratrol is known to have anti-inflammatory properties. However, high-dose resveratrol is required for optimal anti-inflammatory effects. HS-1793 is a derivative...     

烧结温度对La0.6Ca0.4MnO3结构、磁性和磁致热效应的影响（英文）

研究了烧结温度对La0.6Ca0.4MnO3的结构、磁转变和磁熵的影响。观察表明,该化合物属于具有Pnma空间群的斜方晶系结构,不含任何杂质。研究烧结温度对居里温度(TC)的影响,发现提高烧结温度,TC稍有增大。磁致热效应研究显示,随着烧结温度的变化,磁熵会发生显著的变化。在外加磁场为3 T、烧结温度为1300°C时,相对冷却能(RCP)为89 J/kg。因此,该化合物可以考虑作为在室温附近或低于室温的潜在磁制冷材料。     

Effects of international collaboration and status of journal on impact of papers

This study examines the effect of international collaboration of Slovenian authors and the status of journals where papers are published (as determined by their impact factors) on the impact of papers as measured by the number of citations papers receive. Research programme groups working in Slovenia in the 2004–2008 period in the fields of physics, chemistry, biology, biotechnology, and medical science were used for analyses. The results of the analyses show that the effects of the two factors differ among the fields. We discuss possible reasons for this, including the possibility that differences are the result of Slovenia’s science policy.     

Discussion

The use of Stein estimation in multiple linear regression is considered. Tables and graphs are presented that compare the prediction mean squared errors of positive-part James-Stein, preliminary-test, reduced, and full-model least squares estimates. The appropriateness of using Stein contraction on possibly extraneous variables is emphasized, and a procedure is presented for evaluating the likely savings in using Stein estimation on the problem at hand. An example is given.     

Sorption of C. I. Disperse Red 60 in polystyrene and PMMA films and polyester and Nylon 6 textiles in the presence of supercritical carbon dioxide

C. I. Disperse Red 60 (DR60) was absorbed into polymer films and textile fibers in the presence of supercritical carbon dioxide at pressures between 5 and 33MPa and at temperatures between 308.2 and 423.2 K. Polystyrene (PS) and poly(methyl methacrylate) (PMMA) films and polyester (polyethylene terephthalate: PET) and Nylon 6 textiles were used as absorbents. The amount of equilibrium sorption of dye increased both with pressure and temperature. The sorption behavior was successfully analyzed with the quasi dual-mode sorption model.     

Adaptive logarithmic discretization for numerical renormalization group methods

The problem of the logarithmic discretization of an arbitrary positive function (such as the density of states) is studied in general terms. Logarithmic discretization has arbitrary high resolution around some chosen point (such as Fermi level) and it finds application, for example, in the numerical renormalization group (NRG) approach to quantum impurity problems (Kondo model), where the continuum of the conduction band states needs to be reduced to a finite number of levels with good sampling near the Fermi level. The discretization schemes under discussion are required to reproduce the original function after averaging over different interleaved discretization meshes, thus systematic deviations which appear in the conventional logarithmic discretization are eliminated. An improved scheme is proposed in which the discretization-mesh points themselves are determined in an adaptive way; they are denser in the regions where the function has higher values. Such schemes help in reducing the residual numeric artefacts in NRG calculations in situations where the density of states approaches zero over extended intervals. A reference implementation of the solver for the differential equations which determine the full set of discretization coefficients is also described.     

Mechanism of Anticancer Action of Novel Imidazole Platinum(II) Complex Conjugated with G2 PAMAM-OH Dendrimer in Breast Cancer Cells

Transition metal coordination compounds play an important role in the treatment of neoplastic diseases. However, due to their low selectivity and bioavailability, as well as the frequently occurring phenomenon of drug resistance, new chemical compounds that could overcome these phenomena are still being sought. The solution seems to be the synthesis of new metal complexes conjugated with drug carriers, e.g., dendrimers. Numerous literature data have shown that dendrimers improve the bioavailability of the obtained metal complexes, solving the problem of their poor solubility and stability in an aqueous environment and also breaking down inborn and acquired drug resistance. Therefore, the aim of this study was to synthesize a novel imidazole platinum(II) complex conjugated with and without the second-generation PAMAM dendrimer (PtMet2–PAMAM and PtMet2, respectively) and to evaluate its antitumor activity. Cell viability studies indicated that PtMet2–PAMAM exhibited higher cytotoxic activity than PtMet2 in MCF-7 and MDA-MB-231 breast cancer cells at relatively low concentrations. Moreover, our results indicated that PtMet2–PAMAM exerted antiproliferative effects in a zebrafish embryo model. Treatment with PtMet2–PAMAM substantially increased apoptosis in a dose-dependent manner via caspase-9 (intrinsic pathway) and caspase-8 (extrinsic pathway) activation along with pro-apoptotic protein expression modulation. Additionally, we showed that apoptosis can be induced by activating POX, which induces ROS production. Furthermore, our results also clearly showed that the tested compounds trigger autophagy through p38 pathway activation and increase Beclin-1, LC3, AMPK, and mTOR inhibition. The high pro-apoptotic activity and the ability to activate autophagy by the imidazole platinum(II) complex conjugated with a dendrimer may be due to its demonstrated ability to reverse multidrug resistance (MDR) and thereby increase cellular accumulation in breast cancer cells.     

Dynamic exclusive-OR gate based on gate-induced Si islandsingle-electron transistor

Basic operation of a dynamic exclusive-OR gate implemented by a field effect transistor and a single-electron transistor is experimentally demonstrated, for the first time. Logic output voltage shows full swing operation at a supply voltage of 20 mV. Fabricated single-electron transistors are advantageous for implementing a multi-gate single-electron logic circuit     

Stromabfall infolge der Wärmeerzeugung bei der Kraft-Wärme-Kopplung

In the equation of overall energy efficiency of cogeneration, the heat and power are considered as equal terms, what is not in accordance with the second law of thermodynamics. For this reason many attempts were made in the past with intention to reduce the influence of heat in the equation. Therefore several definitions of energy efficiency were set up in course of time, some are presented in this paper and compared with the exergy efficiency. In cogeneration plants the increase of heat production usually causes lower production of electric power. This fact can be described by the heat-to-power-reduction ratio, which is defined as the quotient of the gained heat and decrease in produced electric power. The application of the heat-to-power-reduction ratio is very convenient when evaluations of different definitions of energy efficiency of cogeneration plants are performed. When inserting the heat-to-power-reduction ratio into different definitions of the energy efficiency, we draw the following conclusions: All adapted definitions of the energy efficiency of co-generation plants are redundant and have no sense, some of them are even technically unacceptable. Two definitions remain: energy and exergy efficiency of cogeneration plants. When the influence of the heat is not very significant and when we want to attain a higher price of the heat, the first definition should be used. From a thermodynamic stand of point correct consideration of the processes can be performed only be application of the second definition.     

Negative-differential transconductance characteristics at room temperature in 30-nm square-channel SOI nMOSFETs with a degenerately doped body

Negative-differential transconductance characteristics at room temperature with a peak-to-valley ratio of about two were observed in 30-nm square-channel silicon-on-insulator nMOSFETs with degenerately doped bodies. High channel-doping concentration creates the degeneracy in the p-type body of the self-aligned SOI MOSFET and consequently, enables band-to-band tunneling between degenerate body and source-drain. I/sub DS/-V/sub DS/ curves in the negative drain bias region also show band-to-band tunneling current as in the case of forward-biased p-n tunnel junctions.